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DCN1  -  NEDD8 ligase DCN1

Saccharomyces cerevisiae S288c

Synonyms: Defective in cullin neddylation protein 1, L3111, YLR128W
 
 
 
 
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High impact information on DCN1

  • Both in vivo and in vitro experiments indicate that Dcn1p does not inhibit deneddylation of Cdc53p by the COP9 signalosome, but greatly increases the kinetics of the neddylation reaction [1].

References

  1. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. Kurz, T., Ozlü, N., Rudolf, F., O'Rourke, S.M., Luke, B., Hofmann, K., Hyman, A.A., Bowerman, B., Peter, M. Nature (2005) [Pubmed]
 
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