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ACS2  -  acetate--CoA ligase ACS2

Saccharomyces cerevisiae S288c

Synonyms: Acetate--CoA ligase 2, Acetyl-coenzyme A synthetase 2, Acyl-activating enzyme 2, L9634.10, YLR153C
 
 
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High impact information on ACS2

  • Enzyme activity measurements and mRNA analyses showed that ACS1 and ACS2 were both expressed during carbon-limited growth on glucose, ethanol, and acetate in aerobic chemostat cultures [1].
  • In anaerobic glucose-limited cultures, only the ACS2 gene was expressed [1].
  • The ACS2 upstream region contains an ICRE (inositol/choline-responsive element) as an activating sequence and requires the regulatory genes INO2 and INO4 for maximal expression [2].
  • We demonstrate in vitro binding of the heterodimeric activator protein Ino2p/Ino4p to the ACS2 promoter [2].
  • In addition, the pleiotropic transcription factor Abf1p also binds to the ACS2 control region [2].
 

Biological context of ACS2

  • Strains in which both ACS genes are deleted could only be retrieved when a plasmid containing the ACS2 gene was present, suggesting that the double mutant is lethal [3].
  • Moreover, this analysis revealed that the gene duplication producing Acs1 and Acs2 proteins has occurred in the common ancestor of S. cerevisiae, K. lactis, Candida albicans, C. glabrata and Debaryomyces hansenii lineages [4].
 

Associations of ACS2 with chemical compounds

 

Analytical, diagnostic and therapeutic context of ACS2

References

 
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