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Gene Review

PNP1  -  purine-nucleoside phosphorylase

Saccharomyces cerevisiae S288c

Synonyms: Inosine phosphorylase, Inosine-guanosine phosphorylase, L8167.19, PNP, Purine nucleoside phosphorylase, ...
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High impact information on PNP1


Anatomical context of PNP1

  • The plr1 Delta cells showed low but measurable PL reductase activity catalyzed by some other protein(s) than the enzyme encoded by the plr1(+) gene, which maintained the flow of "PL --> PN --> PNP --> PLP" in the salvage synthesis of PLP [5].

Associations of PNP1 with chemical compounds


  1. Enzymic reactions of phosphate analogs. Gardner, J.H., Byers, L.D. J. Biol. Chem. (1977) [Pubmed]
  2. Investigation of the regiospecificity and stereospecificity of proton transfer in the yeast inorganic pyrophosphatase catalyzed reaction. Lin, I., Knight, W.B., Hsueh, A., Dunaway-Mariano, D. Biochemistry (1986) [Pubmed]
  3. Identification of a pyridoxine (pyridoxamine) 5'-phosphate oxidase from Arabidopsis thaliana. Sang, Y., Barbosa, J.M., Wu, H., Locy, R.D., Singh, N.K. FEBS Lett. (2007) [Pubmed]
  4. YLR209c encodes Saccharomyces cerevisiae purine nucleoside phosphorylase. Lecoq, K., Belloc, I., Desgranges, C., Konrad, M., Daignan-Fornier, B. J. Bacteriol. (2001) [Pubmed]
  5. Disruption of the plr1+ gene encoding pyridoxal reductase of Schizosaccharomyces pombe. Morita, T., Takegawa, K., Yagi, T. J. Biochem. (2004) [Pubmed]
  6. Adenosine accumulation in Saccharomyces cerevisiae cultured in medium containing low levels of adenine. Laten, H.M., Valentine, P.J., van Kast, C.A. J. Bacteriol. (1986) [Pubmed]
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