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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PEX30  -  Pex30p

Saccharomyces cerevisiae S288c

Synonyms: Peroxin-30, Peroxisomal membrane protein PEX30, YLR324W
 
 
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High impact information on PEX30

  • Inp1p binds Pex25p, Pex30p, and Vps1p, which have been implicated in controlling peroxisome division [1].
  • Pex30p and Pex32p control peroxisome size and number but are dispensable for peroxisome formation [2].
  • Pex19p binds Pex30p and Pex32p at regions required for their peroxisomal localization but separate from their peroxisomal targeting signals [2].
  • Mutants of Pex30p and Pex32p that localize to peroxisomes but produce cells exhibiting the peroxisomal phenotypes of cells lacking these proteins demonstrate that the regions in these proteins that control peroxisomal targeting and cell biological activity are separable [2].
 

Other interactions of PEX30

  • Systematic truncations from the carboxyl terminus, together with in-frame deletions of specific regions, have identified PTSs essential for targeting Pex30p and Pex32p to peroxisomes [2].

References

  1. Inp1p is a peroxisomal membrane protein required for peroxisome inheritance in Saccharomyces cerevisiae. Fagarasanu, M., Fagarasanu, A., Tam, Y.Y., Aitchison, J.D., Rachubinski, R.A. J. Cell Biol. (2005) [Pubmed]
  2. Pex19p binds Pex30p and Pex32p at regions required for their peroxisomal localization but separate from their peroxisomal targeting signals. Vizeacoumar, F.J., Vreden, W.N., Aitchison, J.D., Rachubinski, R.A. J. Biol. Chem. (2006) [Pubmed]
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