Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

SSQ1 - Hsp70 family ATPase SSQ1

Saccharomyces cerevisiae S288c

Synonyms: Heat shock protein SSQ1, mitochondrial, SSC2, SSH1, Stress-seventy subfamily Q protein 1, YLR369W, ...

Schilke, B. et al., Huynen, M.A. et al., Strain, J. et al.

Huynen, Snel, Bork, Gibson,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SSQ1

In a synthetic lethal screen with the mitochondrial heat shock protein (HSP)70, SSQ1, we identified a gene of Saccharomyces cerevisiae, NFU1, which encodes a protein with sequence identity to the C-terminal domain of NifU [1].
JAC1, an ortholog of hscB, and SSQ1, a paralog of hscA, have been shown to be required for iron-sulfur cluster assembly in mitochondria of Saccharomyces cerevisiae [2].
One sod1Delta suppressor represents SSQ1 which encodes a hsp70-type molecular chaperone found in the mitochondria [3].

References

Evidence for a conserved system for iron metabolism in the mitochondria of Saccharomyces cerevisiae. Schilke, B., Voisine, C., Beinert, H., Craig, E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
The phylogenetic distribution of frataxin indicates a role in iron-sulfur cluster protein assembly. Huynen, M.A., Snel, B., Bork, P., Gibson, T.J. Hum. Mol. Genet. (2001) [Pubmed]
Suppressors of superoxide dismutase (SOD1) deficiency in Saccharomyces cerevisiae. Identification of proteins predicted to mediate iron-sulfur cluster assembly. Strain, J., Lorenz, C.R., Bode, J., Garland, S., Smolen, G.A., Ta, D.T., Vickery, L.E., Culotta, V.C. J. Biol. Chem. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share