Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CTF3 - Ctf3p

Saccharomyces cerevisiae S288c

Synonyms: CHL3, Central kinetochore subunit CTF3, Chromosome loss protein 3, Chromosome transmission fidelity protein 3, YLR381W

Measday, V. et al., Kouprina NYu, n.u.l.l. et al., Kouprina, N. et al.

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High impact information on CTF3

In addition, Ctf3p, Mcm22p, and Mcm16p have a localization pattern similar to other kinetochore proteins [1].
We find however that Ctf3p is not required for loading of the budding yeast CENP-A homolog, Cse4p, onto CEN DNA [1].
In contrast, Ctf3p and Ctf19p fail to bind properly to the centromere in a cse4-1 mutant strain [1].
The fission yeast Ctf3p homolog, Mis6, is required for loading of a CENP-A centromere specific histone, Cnp1, onto centromere DNA [1].
The CHL3 gene is placed on the right arm of chromosome XII, between the ILV5 (33.3 cM) and URA4 (21.8 cM) loci [2].

Other interactions of CTF3

We have identified four new genetic loci: CHL2 (on chromosome XII), CHL3 (on chromosome XII); CHL4 (on chromosome IV), and CHL5 (on chromosome IX), controlling mitotic transmission of yeast chromosomes [3].

References

Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore. Measday, V., Hailey, D.W., Pot, I., Givan, S.A., Hyland, K.M., Cagney, G., Fields, S., Davis, T.N., Hieter, P. Genes Dev. (2002) [Pubmed]
Identification and genetic mapping of CHL genes controlling mitotic chromosome transmission in yeast. Kouprina, N., Tsouladze, A., Koryabin, M., Hieter, P., Spencer, F., Larionov, V. Yeast (1993) [Pubmed]
Genetic control of chromosome stability in the yeast Saccharomyces cerevisiae. Kouprina NYu, n.u.l.l., Pashina, O.B., Nikolaishwili, N.T., Tsouladze, A.M., Larionov, V.L. Yeast (1988) [Pubmed]

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