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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

STE23  -  Ste23p

Saccharomyces cerevisiae S288c

Synonyms: A-factor-processing enzyme, Insulin-degrading enzyme homolog, L8084.12, YLR389C
 
 
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Psychiatry related information on STE23

  • Pitrilysin is a bacterial protease that is similar to the mammalian insulin-degrading enzyme, which is hypothesized to protect against the onset of Alzheimer's disease, and the yeast enzymes Axl1p and Ste23p, which are responsible for production of the a-factor mating pheromone in Saccharomyces cerevisiae [1].
 

High impact information on STE23

  • We also show that IDE can promote the in vivo production of the yeast a-factor mating pheromone, a function normally attributed to the yeast enzymes Axl1p and Ste23p [2].
 

Biological context of STE23

  • Herein, we report that pitrilysin can be heterologously expressed in yeast such that it functionally substitutes for the shared roles of Axl1p and Ste23p in pheromone production, resulting in a readily observable phenotype [1].

References

  1. A common genetic system for functional studies of pitrilysin and related M16A proteases. Alper, B.J., Nienow, T.E., Schmidt, W.K. Biochem. J. (2006) [Pubmed]
  2. Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme. Kim, S., Lapham, A.N., Freedman, C.G., Reed, T.L., Schmidt, W.K. J. Biol. Chem. (2005) [Pubmed]
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