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Gene Review:

SPP382 - Spp382p

Saccharomyces cerevisiae S288c

Synonyms: CCF8, CLF1 complex factor 8, NTC-related protein 1, NTR1, Nineteen complex-related protein 1, ...

Tsai, R.T. et al., Boon, K.L. et al., Pandit, S. et al.

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High impact information on SPP382

Immunoprecipitation analysis revealed that Ntr1 and Ntr2 formed a stable complex with DExD/H-box RNA helicase Prp43 in the splicing extract [1].
Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2 [1].
Extracts depleted of Ntr1 or Ntr2 exhibited full splicing activity, but accumulated large amounts of lariat-intron in the spliceosome after splicing, indicating that the normal function of the Prp19-associated complex in spliceosome activation was not affected, but spliceosome disassembly was hindered [1].
Weak mutant alleles of SPP382 (also called NTR1) were found to suppress defects in two proteins required for spliceosome activation, Prp38p and Prp8p [2].

Biological context of SPP382

We propose that Ntr1 promotes release of excised introns from splicing complexes by acting as a spliceosome receptor or RNA-targeting factor for Prp43, possibly assisted by the Ntr2 protein [3].

References

Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2. Tsai, R.T., Fu, R.H., Yeh, F.L., Tseng, C.K., Lin, Y.C., Huang, Y.H., Cheng, S.C. Genes Dev. (2005) [Pubmed]
Inhibition of a spliceosome turnover pathway suppresses splicing defects. Pandit, S., Lynn, B., Rymond, B.C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Yeast ntr1/spp382 mediates prp43 function in postspliceosomes. Boon, K.L., Auchynnikava, T., Edwalds-Gilbert, G., Barrass, J.D., Droop, A.P., Dez, C., Beggs, J.D. Mol. Cell. Biol. (2006) [Pubmed]

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