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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PEX22  -  Pex22p

Saccharomyces cerevisiae S288c

Synonyms: Peroxin-22, Peroxisome assembly protein 22, YAL055W
 
 
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High impact information on PEX22

  • Therefore, Pex22p anchors Pex4p at the peroxisomal membrane [1].
  • Cloning the gene by complementation revealed that the encoded protein, Pex22p, is a new peroxin [1].
  • Pex22p, composed of 187 amino acids, is an integral peroxisomal membrane protein with its NH2 terminus in the matrix and its COOH terminus in the cytosol [1].
  • Pex22p and the interacting AAA ATPases Pex1p and Pex6p were also found to act after Pex10p [2].
 

Biological context of PEX22

 

Other interactions of PEX22

  • We demonstrate the ubiquitination of Pex5p in cells lacking components of the peroxisomal AAA (ATPases associated with various cellular activities) or Pex4p-Pex22p complexes of the peroxisomal protein import machinery and in cells affected in proteasomal degradation [3].
  • Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane [1].

References

  1. Pex22p of Pichia pastoris, essential for peroxisomal matrix protein import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal membrane. Koller, A., Snyder, W.B., Faber, K.N., Wenzel, T.J., Rangell, L., Keller, G.A., Subramani, S. J. Cell Biol. (1999) [Pubmed]
  2. The peroxisome biogenesis factors pex4p, pex22p, pex1p, and pex6p act in the terminal steps of peroxisomal matrix protein import. Collins, C.S., Kalish, J.E., Morrell, J.C., McCaffery, J.M., Gould, S.J. Mol. Cell. Biol. (2000) [Pubmed]
  3. Ubiquitination of the peroxisomal import receptor Pex5p. Platta, H.W., Girzalsky, W., Erdmann, R. Biochem. J. (2004) [Pubmed]
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