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Gene Review:

YAT1 - carnitine O-acetyltransferase YAT1

Saccharomyces cerevisiae S288c

Synonyms: YAR035W

Schmalix, W. et al., van den Berg, M.A. et al., Jimeno-Gonz??lez, S. et al.

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Disease relevance of YAT1

In contrast, showing a random nucleosome structure, YAT1 and Escherichia coli lacZ are only mildly influenced by Spt16 depletion [1].

High impact information on YAT1

The gene YAT1 from Saccharomyces cerevisiae encodes a protein of 688 amino acids which displays significant sequence similarity to vertebrate L-carnitine acyltransferases and yeast inner mitochondrial L-carnitine acetyltransferase [2].
The YAT1 promotor region confers the identical carbon source dependence also on the expression of beta-galactosidase when cloned 5' to the Escherichia coli lacZ-coding region [2].
In vitro translated Yat1p, which lacks a cleavable presequence, binds to mitochondria in a protease-sensitive location in a standard in vitro import assay [2].
(iv) The sequence ACGTSCRGAATGA was found in the promoters of the partially ethanol-repressed genes ACS1 and YAT1 [3].

References

A Gene-Specific Requirement for FACT during Transcription Is Related to the Chromatin Organization of the Transcribed Region. Jimeno-Gonz??lez, S., G??mez-Herreros, F., Alepuz, P.M., Ch??vez, S. Mol. Cell. Biol. (2006) [Pubmed]
The ethanol-inducible YAT1 gene from yeast encodes a presumptive mitochondrial outer carnitine acetyltransferase. Schmalix, W., Bandlow, W. J. Biol. Chem. (1993) [Pubmed]
Transient mRNA responses in chemostat cultures as a method of defining putative regulatory elements: application to genes involved in Saccharomyces cerevisiae acetyl-coenzyme A metabolism. van den Berg, M.A., de Jong-Gubbels, P., Steensma, H.Y. Yeast (1998) [Pubmed]

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