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Gene Review:

QRI1 - UDP-N-acetylglucosamine diphosphorylase

Saccharomyces cerevisiae S288c

Synonyms: D2362, UAP1, UDP-N-acetylglucosamine pyrophosphorylase, YDL103C

Mio, T. et al., Mio, T. et al., Lai, K. et al., Yamamoto, K. et al., Simon, M. et al.

Lai, Langley, Khwaja, Schmitt, Elsas,

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High impact information on QRI1

When incubated with Agm1p and Uap1p, the Yfl017c protein produced UDP-N-acetylglucosamine from glucosamine 6-phosphate [1].
In addition, whereas bacterial phosphoglucosamine acetyltransferase and UDP-N-acetylglucosamine pyrophosphorylase activities are intrinsic in a single polypeptide, they are encoded by distinct essential genes in yeast [1].
The yeast Uap1p utilized N-acetylglucosamine-1-phosphate as the substrate, and together with Agm1p, it produced UDP-N-acetylglucosamine from N-acetylglucosamine-6-phosphate [2].
These results demonstrate that the UAP1 genes indeed specify eukaryotic UDP-GlcNAc pyrophosphorylase and that phosphomutase reaction precedes uridyltransfer [2].
Gal-1-P also inhibited UDP-N-acetylglucosamine pyrophosphorylase, which catalyzes the formation of UDP-N-acetylglucosamine [3].

Biological context of QRI1

It contains three open reading frames: QRI1, QRI2 and QRI7 [4].

Associations of QRI1 with chemical compounds

Inhibition of UDP-N-acetylglucosamine pyrophosphorylase by uridine [5].

References

Saccharomyces cerevisiae GNA1, an essential gene encoding a novel acetyltransferase involved in UDP-N-acetylglucosamine synthesis. Mio, T., Yamada-Okabe, T., Arisawa, M., Yamada-Okabe, H. J. Biol. Chem. (1999) [Pubmed]
The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases. Gene cloning, protein expression, and catalytic mechanism. Mio, T., Yabe, T., Arisawa, M., Yamada-Okabe, H. J. Biol. Chem. (1998) [Pubmed]
GALT deficiency causes UDP-hexose deficit in human galactosemic cells. Lai, K., Langley, S.D., Khwaja, F.W., Schmitt, E.W., Elsas, L.J. Glycobiology (2003) [Pubmed]
Sequence of the PHO2-POL3 (CDC2) region of chromosome IV of Saccharomyces cerevisiae. Simon, M., Bénit, P., Vassal, A., Dubois, C., Faye, G. Yeast (1994) [Pubmed]
Inhibition of UDP-N-acetylglucosamine pyrophosphorylase by uridine. Yamamoto, K., Moriguchi, M., Kawai, H., Tochikura, T. Biochim. Biophys. Acta (1980) [Pubmed]

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AgaP_AGAP007889	Anopheles gambiae str. PEST
GlcNA.1UT1	Arabidopsis thaliana
GlcNA.1UT2	Arabidopsis thaliana
AGOS_AFL192C	Ashbya gossypii ATCC 10895
UAP1	Bos taurus
UAP1	Canis lupus familiaris
uap1	Danio rerio
mmy	Drosophila melanogaster
UAP1	Gallus gallus
UAP1	Homo sapiens
KLLA0E01673g	Kluyveromyces lactis NRRL Y-1140
UAP1	Macaca mulatta
MGG_15671	Magnaporthe oryzae 70-15
Uap1	Mus musculus
NCU02109	Neurospora crassa OR74A
Os08g0206900	Oryza sativa Japonica Group
Os04g0613700	Oryza sativa Japonica Group
UAP1	Pan troglodytes
Uap1	Rattus norvegicus
uap1	Schizosaccharomyces pombe 972h-
uap1	Xenopus (Silurana) tropicalis

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