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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RPL4B  -  ribosomal 60S subunit protein L4B

Saccharomyces cerevisiae S288c

Synonyms: 60S ribosomal protein L4-B, L2, RP2, RPL2B, YD8119.17, ...
 
 
 
 
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High impact information on RPL4B

  • The two copies, which encode proteins differing in only a few amino acids, contribute unequally to the L2 mRNA pool: the L2A copy makes 72% of the mRNA, while the L2B copy makes only 28% [1].
 

Biological context of RPL4B

  • The wild-type phenotype was restored in the delta A strains by transformation with extra copies of the intact L2A or L2B gene [1].
 

Anatomical context of RPL4B

  • Disruption of the L2B gene (delta B strain) did not lead to any phenotypic alteration, whereas the inactivation of the L2A copy (delta A strain) produced a slow-growth phenotype associated with decreased accumulation of 60S subunits and ribosomes [1].

References

  1. Gene dosage alteration of L2 ribosomal protein genes in Saccharomyces cerevisiae: effects on ribosome synthesis. Lucioli, A., Presutti, C., Ciafrè, S., Caffarelli, E., Fragapane, P., Bozzoni, I. Mol. Cell. Biol. (1988) [Pubmed]
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