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RPC11  -  DNA-directed RNA polymerase III core...

Saccharomyces cerevisiae S288c

Synonyms: DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerases III 12.5 kDa polypeptide, RNA polymerase III subunit C10, RNA polymerase III subunit C11, YD9609.01C, ...
 
 
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High impact information on RPC11

  • The homology of Rpa12p to the small subunit Rpb9p of Pol II and Rpc11p of Pol III, both implicated in transcriptional termination, points to a common termination mechanism for all three classes of RNA polymerase [1].
  • The Rpc11p subunit of Pol III shows homology with the zinc ribbon of TFIIS and is known to mediate RNA 3' cleavage and to be important for termination [2].

References

  1. Transcriptional termination by RNA polymerase I requires the small subunit Rpa12p. Prescott, E.M., Osheim, Y.N., Jones, H.S., Alen, C.M., Roan, J.G., Reeder, R.H., Beyer, A.L., Proudfoot, N.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing. Huang, Y., Intine, R.V., Mozlin, A., Hasson, S., Maraia, R.J. Mol. Cell. Biol. (2005) [Pubmed]
 
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