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Gene Review:

SSS1 - translocon subunit SSS1

Saccharomyces cerevisiae S288c

Synonyms: D4475, Protein transport protein SSS1, Sec61 complex subunit SSS1, Sec61 complex subunit gamma, Ssh1 complex subunit SSS1, ...

Esnault, Y. et al., Toikkanen, J.H. et al., Esnault, Y. et al., Hartmann, E. et al., Coster, F. et al., et al.

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Disease relevance of SSS1

Moreover, Sec61-gamma and SSS1p are structurally related to SecEp of E. coli and to putative homologues in various other bacteria [1].

High impact information on SSS1

The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum [2].
Thus, the SSS1 gene is required for continued translocation of secretory preproteins beyond their early association to ER membranes [2].
We found that SSS1 is an essential gene required for transfer of secretory precursors through the ER membrane [3].
The sequence contains 20 open reading frames (ORFs) longer than 300 bp as well as the 240 bp gene coding for the essential SSS1 secretory protein [4].
We first inserted the yeast SSS1 gene into the pGEX-2T plasmid expression vector [5].

Physical interactions of SSS1

SSS1 encodes a stabilizing component of the Sec61 subcomplex of the yeast protein translocation apparatus [3].

Other interactions of SSS1

In addition, overexpression of SEC61 or SSS1 encoding the other two components of the Sec61p complex suppressed the growth defects of several exocyst mutants [6].

References

Evolutionary conservation of components of the protein translocation complex. Hartmann, E., Sommer, T., Prehn, S., Görlich, D., Jentsch, S., Rapoport, T.A. Nature (1994) [Pubmed]
The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum. Esnault, Y., Blondel, M.O., Deshaies, R.J., Scheckman, R., Képès, F. EMBO J. (1993) [Pubmed]
SSS1 encodes a stabilizing component of the Sec61 subcomplex of the yeast protein translocation apparatus. Esnault, Y., Feldheim, D., Blondel, M.O., Schekman, R., Képès, F. J. Biol. Chem. (1994) [Pubmed]
Analysis of a 32.8 kb segment of yeast chromosome IV reveals 21 open reading frames, including TPS2, PPH3, RAD55, SED1, PDC2, AFR1, SSS1, SLU7 and a tRNA for arginine. Coster, F., Jonniaux, J.L., Goffeau, A. Yeast (1995) [Pubmed]
Expression, purification, and characterization of Sss1p, an essential component of the yeast Sec61p protein translocation complex. Beswick, V., Brodsky, J.L., Képès, F., Neumann, J.M., Sanson, A., Garrigos, M. Protein Expr. Purif. (1998) [Pubmed]
The beta subunit of the Sec61p endoplasmic reticulum translocon interacts with the exocyst complex in Saccharomyces cerevisiae. Toikkanen, J.H., Miller, K.J., Söderlund, H., Jäntti, J., Keränen, S. J. Biol. Chem. (2003) [Pubmed]

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AGOS_AGR157C	Ashbya gossypii ATCC 10895
KLLA0C11957g	Kluyveromyces lactis NRRL Y-1140

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