Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

FIN1 - Fin1p

Saccharomyces cerevisiae S288c

Synonyms: Filament protein FIN1, Filaments in between nuclei protein 1, YD9302.05C, YDR130C

Mayordomo, I. et al., van Hemert, M.J. et al., Grallert, A. et al., van Hemert, M.J. et al.

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High impact information on FIN1

Compromising Fin1 function leads to SIN activation on both anaphase B SPBs and promotes septation, indicating that Fin1 restrains SIN activity on the old SPB [1].
Filaments of cyano fluorescent protein-tagged Fin1 colocalize with filaments of green fluorescent protein-tagged Tub1 only in large-budded cells [2].
Our results indicate that the Fin1 protein forms a cell cycle-specific filament, additional to the microtubules, between the spindle pole bodies of dividing yeast cells [2].
Here, we describe the interaction of the Fin1 protein with the 14-3-3 proteins Bmh1p and Bmh2p in more detail [3].
The Saccharomyces cerevisiae 14-3-3 protein Bmh2 is required for regulation of the phosphorylation status of Fin1, a novel intermediate filament protein [4].

Biological context of FIN1

In addition, we showed that Glc7, the catalytic subunit of the protein phosphatase 1 complex, was also able to interact with Fin1 [4].

Anatomical context of FIN1

We identified Fin1, a novel intermediate filament protein, as the protein that showed the highest degree of interaction [4].

References

Recruitment of NIMA kinase shows that maturation of the S. pombe spindle-pole body occurs over consecutive cell cycles and reveals a role for NIMA in modulating SIN activity. Grallert, A., Krapp, A., Bagley, S., Simanis, V., Hagan, I.M. Genes Dev. (2004) [Pubmed]
The Saccharomyces cerevisiae Fin1 protein forms cell cycle-specific filaments between spindle pole bodies. van Hemert, M.J., Lamers, G.E., Klein, D.C., Oosterkamp, T.H., Steensma, H.Y., van Heusden, G.P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
Self-association of the spindle pole body-related intermediate filament protein Fin1p and its phosphorylation-dependent interaction with 14-3-3 proteins in yeast. van Hemert, M.J., Deelder, A.M., Molenaar, C., Steensma, H.Y., van Heusden, G.P. J. Biol. Chem. (2003) [Pubmed]
The Saccharomyces cerevisiae 14-3-3 protein Bmh2 is required for regulation of the phosphorylation status of Fin1, a novel intermediate filament protein. Mayordomo, I., Sanz, P. Biochem. J. (2002) [Pubmed]

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