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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CTH1  -  Cth1p

Saccharomyces cerevisiae S288c

Synonyms: Cysteine-three-histidine protein 1, YD8358.07C, YDR151C, mRNA decay factor CTH1
 
 
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High impact information on CTH1

  • Cth1p activity was abolished by E87A and E89A mutations in motif A. Cth1p is nonessential for yeast growth and, by itself, cannot fulfill the essential role played by Cet1p in vivo [1].
  • The 1.1-kb mRNA encoding Cth2p was barely detectable under normal growth conditions; however, disruption of CTH1 resulted in at least a threefold increase in CTH2 mRNA accumulation [2].
  • No change in phenotype was detected following disruption of CTH1 and CTH2, either singly or together [2].
 

Other interactions of CTH1

  • The deduced aa sequences encoded by these genes, designated CTH1 and CTH2, share 46% overall identity and 59% similarity, largely due to the two highly conserved Zf domains [2].

References

  1. Mutational analyses of yeast RNA triphosphatases highlight a common mechanism of metal-dependent NTP hydrolysis and a means of targeting enzymes to pre-mRNAs in vivo by fusion to the guanylyltransferase component of the capping apparatus. Pei, Y., Ho, C.K., Schwer, B., Shuman, S. J. Biol. Chem. (1999) [Pubmed]
  2. Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth. Thompson, M.J., Lai, W.S., Taylor, G.A., Blackshear, P.J. Gene (1996) [Pubmed]
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