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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HXT3  -  Hxt3p

Saccharomyces cerevisiae S288c

Synonyms: D9651.14, Low-affinity glucose transporter HXT3, YDR345C
 
 
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High impact information on HXT3

  • Rgt1 binds in vivo to multiple sites in the HXT3 promoter in a nonadditive, synergistic manner, leading to synergistic repression of HXT3 transcription [1].
  • One suppressor encodes the previously identified glucose transporter HXT1, and another encodes a new member of this family, HXT3 [2].
  • Nevertheless the expression of glucose-repressible HXT3 and SNF3 genes is significantly reduced [3].
  • Expression of multicopy plasmids carrying the HXT1, HXT2, or HXT3 gene allowed partial recovery of both fermentative capacity and catabolite repression in the mutant [4].
 

Biological context of HXT3

  • Transcription of various known glucose transporter genes (HXT1, HXT3, and HXT4) was defective in HTR1 mutants, leading us to suggest that HTR mutations affect a negative factor of HXT gene expression [5].
  • Characterization of glucose transport kinetics indicated the presence of a shift in the low-affinity component that is consistent with a predominant expression of Hxt1p during growth phase and of Hxt3p during stationary phase [6].

References

  1. Specificity and regulation of DNA binding by the yeast glucose transporter gene repressor Rgt1. Kim, J.H., Polish, J., Johnston, M. Mol. Cell. Biol. (2003) [Pubmed]
  2. Roles of multiple glucose transporters in Saccharomyces cerevisiae. Ko, C.H., Liang, H., Gaber, R.F. Mol. Cell. Biol. (1993) [Pubmed]
  3. Transcriptional control of yeast plasma membrane H(+)-ATPase by glucose. Cloning and characterization of a new gene involved in this regulation. García-Arranz, M., Maldonado, A.M., Mazón, M.J., Portillo, F. J. Biol. Chem. (1994) [Pubmed]
  4. The mutation DGT1-1 decreases glucose transport and alleviates carbon catabolite repression in Saccharomyces cerevisiae. Gamo, F.J., Lafuente, M.J., Gancedo, C. J. Bacteriol. (1994) [Pubmed]
  5. Glucose uptake and catabolite repression in dominant HTR1 mutants of Saccharomyces cerevisiae. Ozcan, S., Freidel, K., Leuker, A., Ciriacy, M. J. Bacteriol. (1993) [Pubmed]
  6. Analysis of Saccharomyces cerevisiae hexose carrier expression during wine fermentation: both low- and high-affinity Hxt transporters are expressed. Perez, M., Luyten, K., Michel, R., Riou, C., Blondin, B. FEMS Yeast Res. (2005) [Pubmed]
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