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Gene Review

DIT1  -  Dit1p

Saccharomyces cerevisiae S288c

Synonyms: D9509.21, Spore wall maturation protein DIT1, YDR403W
 
 
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High impact information on DIT1

  • Expression of the DIT and DIT2 genes is restricted to sporulating cells, with the DIT1 transcripts accumulating at the time of prospore enclosure and just prior to the time of dityrosine biosynthesis [1].
  • In addition, the expression of later meiotic transcripts, SPS2 and DIT1, is significantly delayed and reduced [2].
  • The sporulation-specific enzymes encoded by the DIT1 and DIT2 genes catalyze a two-step reaction leading to a soluble LL-dityrosine-containing precursor of the yeast spore wall [3].
  • During meiosis, XBP1 is highly induced and its mRNA appears at the same time as DIT1 mRNA, but its expression remains high for up to 24 h [4].
  • We found that the ability of NREDIT to turn of expression of the reporter gene and the chromosomal DIT1 and DIT2 genes in vegetative cells requires the Ssn6-Tup1 repression complex [5].
 

Biological context of DIT1

  • This element, which prevents expression of the DIT1 and DIT2 genes during vegetative growth, reduces expression of a CYC1-lacZ reporter gene more than 1,000-fold and acts in an orientation- and position-independent manner [5].
  • These are present on an approximately 350-bp DNA fragment extending from NREDIT to the TATA box and an approximately 125-bp fragment spanning the TATA box of DIT1 [5].
  • Additionally, a region of NREDIT which is very similar in sequence to UASSPS4, an element that activates gene expression midway through sporulation, contributes both to vegetative repression and to sporulation-specific induction of DIT1 [5].
 

Associations of DIT1 with chemical compounds

  • By contrast, in dit1 mutants, which lack only the dityrosine layer, bridges are present, suggesting that the bridges may be composed of chitosan [6].
 

Other interactions of DIT1

  • Expression of the yeast genes DIT1 and DIT2 is confined to mid/late sporulation [7].

References

 
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