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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PPM1  -  Ppm1p

Saccharomyces cerevisiae S288c

Synonyms: Leucine carboxyl methyltransferase 1, Protein phosphatase methyltransferase 1, YDR435C
 
 
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High impact information on PPM1

  • Inactivation of PPM1 or overexpression of PPE1, the yeast gene homologous to bovine methylesterase, yields phenotypes similar to those observed after inactivation of either regulatory subunit [1].
  • We have determined the structure of PPM1, the yeast methyltransferase responsible for methylation of PP2A [2].
  • The structure of PPM1 reveals a common S-adenosyl-l-methionine-dependent methyltransferase fold, with several insertions conferring the specific function and substrate recognition [2].
  • To experimentally identify the PP2A methyltransferase in yeast, we obtained deletion mutants of PPM1 and PPM2 and then constructed double mutants [3].
 

Biological context of PPM1

  • Using in vivo-labeling techniques, we demonstrate that only the PPM1 gene is required for PP2Ac methylation at the C-terminus [3].

References

  1. Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo. Wu, J., Tolstykh, T., Lee, J., Boyd, K., Stock, J.B., Broach, J.R. EMBO J. (2000) [Pubmed]
  2. Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity. Leulliot, N., Quevillon-Cheruel, S., Sorel, I., de La Sierra-Gallay, I.L., Collinet, B., Graille, M., Blondeau, K., Bettache, N., Poupon, A., Janin, J., van Tilbeurgh, H. J. Biol. Chem. (2004) [Pubmed]
  3. Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast. Kalhor, H.R., Luk, K., Ramos, A., Zobel-Thropp, P., Clarke, S. Arch. Biochem. Biophys. (2001) [Pubmed]
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