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Gene Review

TSA2  -  thioredoxin peroxidase TSA2

Saccharomyces cerevisiae S288c

Synonyms: Cytoplasmic thiol peroxidase 2, D9461.38, Peroxiredoxin TSA2, Thiol-specific antioxidant protein 2, Thioredoxin peroxidase 2, ...
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High impact information on TSA2

  • This specific sensitivity of DeltacTPxII cells to TBHP could not be related to the expression pattern of TSA2 (cytosolic thioredoxin peroxidase II gene) either, since this gene is highly inducible by both H(2)O(2) and TBHP when cells were grown in different conditions [1].
  • In addition, TSA2 was activated in tsa1Delta cells in a Yap1p-dependent manner [2].
  • The demonstration of a peroxynitrite reductase activity of Tsa2p in vitro points to a pivotal role for peroxiredoxins in the protection against nitrosative stress [2].
  • We observed that the transcription of Saccharomyces cerevisiae cytoplasmic thiol peroxidase type II (cTPx II) (YDR453C) is regulated in response to various stresses (e.g. oxidative stress, carbon starvation, and heat-shock) [3].

Biological context of TSA2


Other interactions of TSA2

  • Here we report on the functional characterization of yeast tsa2Delta mutants and the comparison of TSA1 with TSA2 [2].


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