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Gene Review

SLF1  -  Slf1p

Saccharomyces cerevisiae S288c

Synonyms: D9719.20, Protein SLF1, YDR515W
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High impact information on SLF1

  • Identification of SLF1 as a new copper homeostasis gene involved in copper sulfide mineralization in Saccharomyces cerevisiae [1].
  • Disruption of SLF1, which is located close to the telomere region of chromosome IV, leads to limited copper sensitivity, and the resulting cells lack the normal brownish coloration when grown in CuSO4-containing medium [1].
  • Slf1 is important for the physiological process of copper sulfide (CuS) mineralization on the surface of cells cultured in medium containing copper salts [1].
  • Overproduction of Slf1 in wild-type cells confers superresistance to CuSO4 and enhances the coloration of cells cultured in the presence of CuSO4 [1].
  • We show that deletions in both SRO9 and SLF1 are not synthetically lethal with a deletion in LHP1, indicating that the three proteins do not function in a single essential process [2].

Anatomical context of SLF1

  • We demonstrate that Sro9p and Slf1p are RNA-binding proteins that associate preferentially with translating ribosomes [2].


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