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Gene Review:

SRO77 - Sro77p

Saccharomyces cerevisiae S288c

Synonyms: Lethal(2) giant larvae protein homolog SRO77, SNI2, SOP2, Sodium protection protein 2, Suppressor of RHO3 protein 77, ...

Rehman, A. et al., Zhang, X. et al., Kim, Y.S. et al., Larsson, K. et al., Lehman, K. et al., et al.

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Disease relevance of SRO77

The observed enhanced survival at pH 3 of Rhizobium sp. NBRI2505 sesbania and T112 in the presence of 5% CaCO(3) suggests the requirement of calcium for growth and survival, which may have an ecological significance in acidic soils [1].

High impact information on SRO77

In this study, we report that the yeast Lgl proteins Sro7p and Sro77p directly interact with Exo84p, which is a component of the exocyst complex that is essential for targeting vesicles to specific sites of the plasma membrane for exocytosis, and that this interaction is important for post-Golgi secretion [2].
However, a yeast strain deleted for both SRO7 and its homologue SRO77 exhibits NaCl-induced cell death that is independent on YCA1 [3].

Biological context of SRO77

SRO7 and SRO77 have redundant functions as loss of both gene products leads to a severe cold-sensitive growth defect that correlates with a severe defect in exocytosis [4].
Cells carrying a sop1Deltasop2Delta double deletion became, however, hypersensitive to Na+ and exhibited increased sensitivity also to Li+ and K+, suggesting involvement of both SOP1 and SOP2 in cation homeostasis [5].
Mammalian homologues of the Lethal giant larvae (Lgl) tumor suppressor gene have been identified and these homologues can complement the yeast double mutant of Sop1 and Sop2, the yeast homologue of Lgl, as reported previously [6].

Analytical, diagnostic and therapeutic context of SRO77

T112 was specifically defective in its tolerance for drought: when subjected to drought stress, it tolerated YEB containing 45% PEG for up to 2 days of incubation at 30 degrees C. T122 mutant was also more sensitive to the heat and desiccation stresses, compared with Rhizobium sp. NBRI2505 sesbania in the presence of 45% PEG [1].

References

Effect of drought on the growth and survival of the stress-tolerant bacterium Rhizobium sp. NBRI2505 sesbania and its drought-sensitive transposon Tn 5 mutant. Rehman, A., Nautiyal, C.S. Curr. Microbiol. (2002) [Pubmed]
Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis. Zhang, X., Wang, P., Gangar, A., Zhang, J., Brennwald, P., TerBush, D., Guo, W. J. Cell Biol. (2005) [Pubmed]
Yeast lacking the SRO7/SOP1-encoded tumor suppressor homologue show increased susceptibility to apoptosis-like cell death on exposure to NaCl stress. Wadskog, I., Maldener, C., Proksch, A., Madeo, F., Adler, L. Mol. Biol. Cell (2004) [Pubmed]
Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9. Lehman, K., Rossi, G., Adamo, J.E., Brennwald, P. J. Cell Biol. (1999) [Pubmed]
The Saccharomyces cerevisiae SOP1 and SOP2 genes, which act in cation homeostasis, can be functionally substituted by the Drosophila lethal(2)giant larvae tumor suppressor gene. Larsson, K., Böhl, F., Sjöström, I., Akhtar, N., Strand, D., Mechler, B.M., Grabowski, R., Adler, L. J. Biol. Chem. (1998) [Pubmed]
Disruption of protein-protein interaction in the Mgl-1 oncoprotein. Kim, Y.S., Kim, Y.K., Park, J.M., Han, I.S., Ajjappala, B.S., Kang, I., Baek, K.H. Oncol. Rep. (2006) [Pubmed]

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