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Gene Review

KIP1  -  Kip1p

Saccharomyces cerevisiae S288c

Synonyms: CIN9, Chromosome instability protein 9, Kinesin-like protein KIP1, YBL0504, YBL0521, ...
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High impact information on KIP1


Biological context of KIP1

  • The kinesin-related products of the CIN8 and KIP1 genes of Saccharomyces cerevisiae redundantly perform an essential function in mitosis [4].
  • These mutations also suppressed the inviability associated with the cin8-delta kip1-delta genotype, a property not shared by a deletion of KAR3 [4].
  • Microtubule depolymerization may also be the mechanism by which Kar3p acts in opposition to the anaphase B motors Cin8p and Kip1p [5].
  • KIP1 is present in a single copy in the genome, and is expressed predominantly in pollen with a similar temporal pattern to PRK1 [6].
  • The amino acid sequence of KIP1 deduced from full-length cDNA contains an EF-hand Ca(2+)-binding motif and nine predicted coiled-coil regions [6].

Anatomical context of KIP1

  • The microtubule organizing centers of arrested cells were duplicated but unseparated, indicating that KIP1 or CIN8 is required for mitotic spindle assembly [2].
  • Since ectopic expression of proteolysis-resistant Cin8, Kip1 or Ase1 is sufficient for SPB separation even in the absence of Cdc28-Clb activity, we suggest that stabilization of these mechanical force-generating proteins is the predominant role of Cdc28-Clb in centrosome separation [7].
  • These include genes whose products act in two spindle motor pathways that overlap in function with Cin8p, the kinesin-related Kip1p pathway and the cytoplasmic dynein pathway [8].

Associations of KIP1 with chemical compounds

  • Conditionally lethal double mutants containing the temperature sensitive allele cin8-3 in a background deletion of either kip1 or dyn1 grew normally at the restrictive temperature when osmolytes such as sorbitol were added to the medium [9].

Regulatory relationships of KIP1


Other interactions of KIP1

  • We have selected mutations that suppress the temperature-sensitivity of a cin8-temperature-sensitive kip1-delta strain [4].
  • Our findings suggest that despite an antagonistic relationship between Cin8p/Kip1p and Kar3p, aspects of their mitotic roles may be similar [4].
  • Sequencing and functional analysis of a 32,560 bp segment on the left arm of yeast chromosome II. Identification of 26 open reading frames, including the KIP1 and SEC17 genes [10].
  • Finally, overexpression of the KIP1 gene in vivo in Saccharomyces cerevisiae, like overexpression of the related SIC1 gene, rescues the cell cycle-related phenotype of a sic1Delta strain [11].

Analytical, diagnostic and therapeutic context of KIP1


  1. Kinesin-related proteins required for structural integrity of the mitotic spindle. Saunders, W.S., Hoyt, M.A. Cell (1992) [Pubmed]
  2. Kinesin-related proteins required for assembly of the mitotic spindle. Roof, D.M., Meluh, P.B., Rose, M.D. J. Cell Biol. (1992) [Pubmed]
  3. Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly. Hoyt, M.A., He, L., Loo, K.K., Saunders, W.S. J. Cell Biol. (1992) [Pubmed]
  4. Loss of function of Saccharomyces cerevisiae kinesin-related CIN8 and KIP1 is suppressed by KAR3 motor domain mutations. Hoyt, M.A., He, L., Totis, L., Saunders, W.S. Genetics (1993) [Pubmed]
  5. The Saccharomyces cerevisiae kinesin-related motor Kar3p acts at preanaphase spindle poles to limit the number and length of cytoplasmic microtubules. Saunders, W., Hornack, D., Lengyel, V., Deng, C. J. Cell Biol. (1997) [Pubmed]
  6. Isolation and characterization of kinase interacting protein 1, a pollen protein that interacts with the kinase domain of PRK1, a receptor-like kinase of petunia. Skirpan, A.L., McCubbin, A.G., Ishimizu, T., Wang, X., Hu, Y., Dowd, P.E., Ma, H., Kao, T. Plant Physiol. (2001) [Pubmed]
  7. Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins. Crasta, K., Huang, P., Morgan, G., Winey, M., Surana, U. EMBO J. (2006) [Pubmed]
  8. Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways. Geiser, J.R., Schott, E.J., Kingsbury, T.J., Cole, N.B., Totis, L.J., Bhattacharyya, G., He, L., Hoyt, M.A. Mol. Biol. Cell (1997) [Pubmed]
  9. Mutations in the yeast kinesin-like Cin8p are alleviated by osmotic support. Korolyev, E., Steinberg-Neifach, O., Eshel, D. FEMS Microbiol. Lett. (2005) [Pubmed]
  10. Sequencing and functional analysis of a 32,560 bp segment on the left arm of yeast chromosome II. Identification of 26 open reading frames, including the KIP1 and SEC17 genes. Scherens, B., el Bakkoury, M., Vierendeels, F., Dubois, E., Messenguy, F. Yeast (1993) [Pubmed]
  11. The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Barberis, M., De Gioia, L., Ruzzene, M., Sarno, S., Coccetti, P., Fantucci, P., Vanoni, M., Alberghina, L. Biochem. J. (2005) [Pubmed]
  12. The kinesin-related protein Kip1p of Saccharomyces cerevisiae is bipolar. Gordon, D.M., Roof, D.M. J. Biol. Chem. (1999) [Pubmed]
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