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Gene Review:

IML3 - Iml3p

Saccharomyces cerevisiae S288c

Synonyms: Central kinetochore subunit IML3, Increased minichromosome loss protein 3, MCM19, Minichromosome maintenance protein 19, YBR0836, ...

Ghosh, S.K. et al., Ghosh, S.K. et al., Pot, I. et al.

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High impact information on IML3

Chl4p and iml3p are two new members of the budding yeast outer kinetochore [1].
The Iml3 protein of the budding yeast is required for the prevention of precocious sister chromatid separation in meiosis I and for sister chromatid disjunction in meiosis II [2].
We show that one such protein, Iml3, is essential for meiosis, in that the absence of this protein results in reduced spore viability, precocious sister chromatid segregation of artificial and natural chromosomes in meiosis I and chromosome non-disjunction in meiosis II [2].
The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation [3].
However, the mcm19 null mutation conferred growth defects in the presence of a mutation in the TUB1 gene coding for alpha-tubulin [3].

Biological context of IML3

Two-hybrid experiments showed an interaction between Im13p/Mcm19p and the kinetochore protein Ch14, indicating that the Im13/Mcm19 protein has a role in kinetochore function [3].

References

Chl4p and iml3p are two new members of the budding yeast outer kinetochore. Pot, I., Measday, V., Snydsman, B., Cagney, G., Fields, S., Davis, T.N., Muller, E.G., Hieter, P. Mol. Biol. Cell (2003) [Pubmed]
The Iml3 protein of the budding yeast is required for the prevention of precocious sister chromatid separation in meiosis I and for sister chromatid disjunction in meiosis II. Ghosh, S.K., Sau, S., Lahiri, S., Lohia, A., Sinha, P. Curr. Genet. (2004) [Pubmed]
The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation. Ghosh, S.K., Poddar, A., Hajra, S., Sanyal, K., Sinha, P. Mol. Genet. Genomics (2001) [Pubmed]

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