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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ECM31  -  3-methyl-2-oxobutanoate...

Saccharomyces cerevisiae S288c

Synonyms: Extracellular matrix protein 31, Ketopantoate hydroxymethyltransferase, YBR1238, YBR176W
 
 
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Disease relevance of ECM31

 

High impact information on ECM31

  • Furthermore, yeast genes ECM31 and YIL145c, which both have structural homology to genes of the bacterial pantothenic acid pathway, were also required for pantothenic acid biosynthesis [2].
  • KPHMT enzyme activity could be measured in purified mitochondria from both pea leaves and Arabidopsis suspension cultures [3].
  • Two genes encoding KPHMT and one for PtS were identified in the Arabidopsis thaliana genome, and cDNAs for all three genes were amplified by PCR [3].
  • DNA sequence analysis revealed that the DNA fragment encodes ECM31, the deletion of which had previously been identified as a calcofluor white-sensitive mutation [1].
  • 7 haploid and the ecm31 disruptant required pantothenic acid at 35 degrees C for its growth, suggesting that Kyokai no [1].

References

  1. Molecular cloning and application of a gene complementing pantothenic acid auxotrophy of sake yeast Kyokai no. 7. Shimoi, H., Okuda, M., Ito, K. J. Biosci. Bioeng. (2000) [Pubmed]
  2. Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. White, W.H., Gunyuzlu, P.L., Toyn, J.H. J. Biol. Chem. (2001) [Pubmed]
  3. Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. Ottenhof, H.H., Ashurst, J.L., Whitney, H.M., Saldanha, S.A., Schmitzberger, F., Gweon, H.S., Blundell, T.L., Abell, C., Smith, A.G. Plant J. (2004) [Pubmed]
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