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Gene Review:

DPB3 - Dpb3p

Saccharomyces cerevisiae S288c

Synonyms: DNA polymerase II subunit C, DNA polymerase epsilon subunit C, YBR2015, YBR278W

Iida, T. et al., Araki, H. et al., Tsubota, T. et al., Li, Y. et al., Holmstrøm, K. et al.

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High impact information on DPB3

Here we show that the epigenetic states of the telomere gene are not stably inherited in cells either bearing a mutation in a catalytic subunit (Pol2) of replicative DNA polymerase epsilon (Pol epsilon) or lacking one of the nonessential and histone fold motif-containing subunits of Pol epsilon, Dpb3 and Dpb4 [1].
The lysine-substituted dpb3 mutants also displayed reduced telomeric silencing, whose degree paralleled that of the dsDNA-binding activity of Pol epsilon in the corresponding dpb3 mutants [2].
Both proteins contain histone fold motifs which are present also in S. cerevisiae DPB4 and DPB3 [3].
DPB3 was mapped to chromosome II, 30 cM distal to his7 [4].
The nucleotide sequence of DPB3 contained an open reading frame encoding a 23-kDa protein, significantly smaller than the observed molecular masses, 34- or 30-kDa, which might represent post-translationally modified forms of the DPB3 product [4].

Other interactions of DPB3

Four genes had already been cloned and sequenced: part of RIF1, DPB3, MRP-L27 and SNF5 [5].

References

Noncompetitive counteractions of DNA polymerase epsilon and ISW2/yCHRAC for epigenetic inheritance of telomere position effect in Saccharomyces cerevisiae. Iida, T., Araki, H. Mol. Cell. Biol. (2004) [Pubmed]
Double-stranded DNA Binding, an Unusual Property of DNA Polymerase {epsilon}, Promotes Epigenetic Silencing in Saccharomyces cerevisiae. Tsubota, T., Tajima, R., Ode, K., Kubota, H., Fukuhara, N., Kawabata, T., Maki, S., Maki, H. J. Biol. Chem. (2006) [Pubmed]
Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. Li, Y., Pursell, Z.F., Linn, S. J. Biol. Chem. (2000) [Pubmed]
Cloning DPB3, the gene encoding the third subunit of DNA polymerase II of Saccharomyces cerevisiae. Araki, H., Hamatake, R.K., Morrison, A., Johnson, A.L., Johnston, L.H., Sugino, A. Nucleic Acids Res. (1991) [Pubmed]
The sequence of a 32,420 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae. Holmstrøm, K., Brandt, T., Kallesøe, T. Yeast (1994) [Pubmed]

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