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Gene Review: 

SSH1  -  Ssh1p

Saccharomyces cerevisiae S288c

Synonyms: Sec sixty-one protein homolog, Ssh1 complex subunit SSH1, Ssh1 complex subunit alpha, YBR2020, YBR283C
 
 
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High impact information on SSH1

  • Unlike SSC1 mutants, an SSH1 mutant showed no detectable defects in import of several proteins from the cytosol to the matrix compared to wild type [1].
  • Spontaneous suppressors of the cold-sensitive phenotype of an SSH1 null mutant were obtained at a high frequency at 23 degrees C, and were all found to be respiration deficient [1].
  • SSH1, a newly identified member of the heat shock protein (hsp70) multigene family of the budding yeast Saccharomyces cerevisiae, encodes a protein localized to the mitochondrial matrix [1].
  • Deletion of the SSH1 gene results in extremely slow growth at 23 degrees C or 30 degrees C, but nearly wild-type growth at 37 degrees C. The matrix of the mitochondria contains another hsp70, Ssc1, which is essential for growth and required for translocation of proteins into mitochondria [1].
  • In addition, loss of the SEC61-related gene, SSH1, also has no effect on peroxisome biogenesis [2].
 

Associations of SSH1 with chemical compounds

  • Deletion of SSH1, which encodes a ribosome-binding Sec61p homologue in the ER, had no effect on glycopeptide export [3].

References

  1. The cold sensitivity of a mutant of Saccharomyces cerevisiae lacking a mitochondrial heat shock protein 70 is suppressed by loss of mitochondrial DNA. Schilke, B., Forster, J., Davis, J., James, P., Walter, W., Laloraya, S., Johnson, J., Miao, B., Craig, E. J. Cell Biol. (1996) [Pubmed]
  2. Inactivation of the endoplasmic reticulum protein translocation factor, Sec61p, or its homolog, Ssh1p, does not affect peroxisome biogenesis. South, S.T., Baumgart, E., Gould, S.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. The protein translocation channel mediates glycopeptide export across the endoplasmic reticulum membrane. Gillece, P., Pilon, M., Römisch, K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
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