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Gene Review:

TAD1 - Tad1p

Saccharomyces cerevisiae S288c

Synonyms: HRA400, YGL243W, tRNA-specific adenosine deaminase 1, tRNA-specific adenosine-37 deaminase

Keegan, L.P. et al., Drivinya, A. et al., Dietz, M. et al.

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High impact information on TAD1

The enzyme has no activity on dsRNA substrates but is a tRNA deaminase with specificity for adenosine 37 of insect alanine tRNA. dADAT1 shows greater similarity to vertebrate ADARs than to yeast Tad1p, supporting the hypothesis of a common evolutionary origin for ADARs and ADATs. dAdat1 transcripts are maternally supplied in the egg [1].
In this work, we describe a molecular analysis of functional minimal domains responsible for specific DNA recognition and transcriptional activation (TAD1 and TAD2) [2].

Analytical, diagnostic and therapeutic context of TAD1

We report here the isolation of a stable ura5 mutant of C. neoformans, designated as TAD1, by eliminating the URA5 gene by homologous recombination using the biolistic DNA delivery system [3].

References

The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification. Keegan, L.P., Gerber, A.P., Brindle, J., Leemans, R., Gallo, A., Keller, W., O'Connell, M.A. Mol. Cell. Biol. (2000) [Pubmed]
TFIIB and subunits of the SAGA complex are involved in transcriptional activation of phospholipid biosynthetic genes by the regulatory protein Ino2 in the yeast Saccharomyces cerevisiae. Dietz, M., Heyken, W.T., Hoppen, J., Geburtig, S., Schüller, H.J. Mol. Microbiol. (2003) [Pubmed]
Construction of a complete URA5 deletion strain of a human pathogenic yeast Cryptococcus neoformans. Drivinya, A., Shimizu, K., Takeo, K. Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology. (2004) [Pubmed]

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