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Gene Review

FZF1  -  Fzf1p

Saccharomyces cerevisiae S288c

Synonyms: NCR299, NRC299, RSU1, SUL1, Sulfite resistance protein 1, ...
 
 
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High impact information on FZF1

  • Transcriptional induction of SSU1, which encodes a putative sulfite transporter, has previously been shown to require the zinc finger transcription factor Fzf1p [1].
  • A cis-acting sequence unique to the promoter regions of Fzf1p-dependent genes was found to be sufficient to activate reporter gene activity in an *NO- and Fzf1p-dependent manner [1].
  • In the present study, we show that lack of the cadmium glutathione-conjugate vacuolar pump Ycf1p or overexpression of the sulphite resistance membrane protein Ssu1p enhance the capacity of yeast cells to resist selenite treatment [2].
  • The three other genes, called SUL1, SUL2 and SUL3, encode proteins involved in sulfate transport [3].
  • Multicopy FZF1, a putative transcription factor, was found to suppress the sulfite sensitive phenotype of grr1 strains, but not the glucose derepression or aberrant cell morphology [4].
 

Biological context of FZF1

  • The SSU1 promoter region involved in activation by FZF1 was defined, and the FZF1 protein was shown to bind to it directly in vitro [5].
  • In the course of a comprehensive genomic screen for cell cycle regulated genes in the yeast Saccharomyces cerevisiae (Price et al., 1991) we identified and characterized a transcriptional unit encoding a putative zinc finger protein named FZF1 (EMBL accession number: X67787) [6].
 

Anatomical context of FZF1

  • Previous work based on multicopy suppression analysis placed FZF1 upstream of SSU1, which encodes a plasma membrane protein and putative transporter also implicated in sulphite detoxification [5].
 

Associations of FZF1 with chemical compounds

 

Other interactions of FZF1

  • Multicopy suppression analysis, undertaken to explore relationships among genes previously implicated in sulfite metabolism, suggests a regulatory pathway in which SSU1 acts downstream of FZF1 and SSU3, which in turn act downstream of GRR1 [8].

References

 
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