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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

LSG1  -  putative GTPase LSG1

Saccharomyces cerevisiae S288c

Synonyms: Large subunit GTPase 1, YGL099W
 
 
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High impact information on LSG1

  • Mutations in LSG1 or RPL10 blocked Nmd3-GFP shuttling into the nucleus and export of pre-60S subunits from the nucleus [1].
  • These results support the idea that Sqt1p loads Rpl10p onto the Nmd3p-bound subunit after export to the cytoplasm and that Rpl10p loading involves the GTPase Lsg1p [2].
  • We have recently shown that Rpl10p as well as the cytoplasmic GTPase Lsg1p are required for releasing the 60S nuclear export adapter Nmd3p from subunits in the cytoplasm [2].
  • The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively [3].
 

Biological context of LSG1

  • Conditional mutants of both NOG1 and LSG1 are defective in 60S subunit biogenesis and display diminished levels of 60S subunits at restrictive temperature [3].
  • Since Lsg1p is cytoplasmic, its role in nuclear export is likely to be indirect [3].
 

Other interactions of LSG1

  • This mutant Lsg1 protein also leads to increased levels of Sqt1p in complexes that are coimmunoprecipitated with Nmd3p [2].

References

  1. Release of the export adapter, Nmd3p, from the 60S ribosomal subunit requires Rpl10p and the cytoplasmic GTPase Lsg1p. Hedges, J., West, M., Johnson, A.W. EMBO J. (2005) [Pubmed]
  2. Defining the order in which Nmd3p and Rpl10p load onto nascent 60S ribosomal subunits. West, M., Hedges, J.B., Chen, A., Johnson, A.W. Mol. Cell. Biol. (2005) [Pubmed]
  3. The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively. Kallstrom, G., Hedges, J., Johnson, A. Mol. Cell. Biol. (2003) [Pubmed]
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