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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review

TFC4  -  Tfc4p

Saccharomyces cerevisiae S288c

Synonyms: PCF1, TFIIIC 131 kDa subunit, Transcription factor C subunit 4, Transcription factor tau 131 kDa subunit, YGR047C
 
 
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High impact information on TFC4

  • We also show that alternative alignments between DNA-bound TFIIIB and TFIIIC are possible, implying a remarkably flexible linkage, and suggest that Tfc4, the TFIIIB-assembling subunit of TFIIIC, could be responsible for such elasticity [1].
  • A Bdp1 deletion near essential segment I was synthetically lethal with overexpression of PCF1-1, a dominant gain-of-function mutation in the second tetracopeptide repeat motif (out of 11) of the Tfc4 (tau(131)) subunit of TFIIIC [2].
  • Here, we report that PCF1 encodes the second largest subunit of transcription factor IIIC (TFIIIC) and that the PCF1-1 mutation causes an amino acid substitution in a novel protein structural motif, a tetratricopeptide repeat, in this subunit [3].
  • Tfc4 contains two arrays of tetratricopeptide repeats (TPRs), each of which provides a binding site for Brf1 [4].
  • Genetic linkage and complementation studies suggest that all 14 isolates contain recessive alleles of PCF1 [5].
 

Physical interactions of TFC4

  • Dominant mutations in the ligand binding channel of the first TPR array, TPRs1-5, and on the back side of this array, increase Brf1 binding by Tfc4 [4].
  • Indeed, the L469K mutation also decreased the binding affinity for Bdp1 incorporation into TFIIIB-TFIIIC-DNA complexes and inhibited binary interactions between Bdp1 and Tfc4 [4].

References

 
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