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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PEX8  -  Pex8p

Saccharomyces cerevisiae S288c

Synonyms: PAS6, Peroxin-8, Peroxisomal biogenesis factor 8, Peroxisomal protein PAS6, YGR077C
 
 
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High impact information on PEX8

  • The pex8Delta mutant phenotype and the observed PTS1-independent interaction with the PTS1 receptor suggest that Pex8p is involved in protein import into the peroxisomal matrix [1].
  • In pex8Delta cells, the PTS1 and PTS2 receptor still associate with membrane bound components of the protein import machinery, supporting the assumption that the Pex8p function in protein translocation follows the docking event [1].
  • Cells lacking Pex8p are characterized by the presence of peroxisomal membrane ghosts and mislocalization of peroxisomal matrix proteins of the PTS1 and PTS2 variety to the cytosol [1].
  • The deduced product of YLR284C contains a type 1 peroxisomal targeting signal-like sequence at its C terminus and localizes to the peroxisome in a PEX8-dependent manner [2].
  • A computer-based screen identified Yor180Cp as a putative peroxisomal protein, and Yor180Cp targeted GFP to peroxisomes in a PEX8-dependent manner [3].
 

Other interactions of PEX8

  • Consistent with its intraperoxisomal localization, Pex8p contains a peroxisomal targeting signal 1, and it interacts with the PTS1 receptor Pex5p [1].

References

  1. Pex8p, an intraperoxisomal peroxin of Saccharomyces cerevisiae required for protein transport into peroxisomes binds the PTS1 receptor pex5p. Rehling, P., Skaletz-Rorowski, A., Girzalsky, W., Voorn-Brouwer, T., Franse, M.M., Distel, B., Veenhuis, M., Kunau, W.H., Erdmann, R. J. Biol. Chem. (2000) [Pubmed]
  2. Molecular characterization of Saccharomyces cerevisiae Delta3, Delta2-enoyl-CoA isomerase. Geisbrecht, B.V., Zhu, D., Schulz, K., Nau, K., Morrell, J.C., Geraghty, M., Schulz, H., Erdmann, R., Gould, S.J. J. Biol. Chem. (1998) [Pubmed]
  3. Preliminary characterization of Yor180Cp: identification of a novel peroxisomal protein of saccharomyces cerevisiae involved in fatty acid metabolism. Geisbrecht, B.V., Schulz, K., Nau, K., Geraghty, M.T., Schulz, H., Erdmann, R., Gould, S.J. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
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