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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TPO2  -  Tpo2p

Saccharomyces cerevisiae S288c

Synonyms: G6417, Polyamine transporter 2, YGR138C
 
 
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High impact information on TPO2

  • Using sucrose gradient ultracentrifugation we found that an hemagglutinin (HA)-tagged Tpo1p as well as its HA-tagged Tpo2p-4p homologues co-localize with plasma membrane markers [1].
  • Membrane proteins encoded by the open reading frames YGR138c (TPO2), YPR156c (TPO3) and YOR273c (TPO4) were postulated to be polyamine transporters and, indeed, were subsequently shown to be polyamine transport proteins on the vacuolar membrane [2].
  • The Haa1-regulated genes required for a more rapid yeast adaptation to weak acids include TPO2 and TPO3, encoding two predicted plasma membrane multidrug transporters of the major facilitator superfamily, and YGP1, encoding a poorly characterized cell wall glycoprotein [3].

References

  1. Localization and function of the yeast multidrug transporter Tpo1p. Albertsen, M., Bellahn, I., Krämer, R., Waffenschmidt, S. J. Biol. Chem. (2003) [Pubmed]
  2. Multiple polyamine transport systems on the vacuolar membrane in yeast. Tomitori, H., Kashiwagi, K., Asakawa, T., Kakinuma, Y., Michael, A.J., Igarashi, K. Biochem. J. (2001) [Pubmed]
  3. Saccharomyces cerevisiae adaptation to weak acids involves the transcription factor Haa1p and Haa1p-regulated genes. Fernandes, A.R., Mira, N.P., Vargas, R.C., Canelhas, I., Sá-Correia, I. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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