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Gene Review:

SUF4 - tRNA

Saccharomyces cerevisiae S288c

Celenza, J.L. et al., Praekelt, U.M. et al., Culbertson, M.R. et al., Mendenhall, M.D. et al.

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High impact information on SUF4

The frameshift suppressor genes suf1+, suf4+ and suf6+ were shown to encode the wild-type tRNA(UCC) tRNA [1].
We have shown by tetrad analysis that SUF4 is linked to cly8 and ade6 [2].
These data indicate that the genetic map of the right arm of chromosome VII should be revised by inverting the orientation of the distal segment so that SUF4 is located near cly8, and SUC1 and MAL1 are the most distal markers [2].
The 5' region of MOL1 contains the complete sequence previously determined for the SUF4 locus, encoding a tRNA-gly (UCC) gene, which has been mapped to chromosome VII [3].

Other interactions of SUF4

In addition, strains carrying SUF1, SUF4 or SUF6 are phenotypically unstable and give rise to mitotic Suf+ segments at high frequency [4].

References

Frameshift suppressor mutations affecting the major glycine transfer RNAs of Saccharomyces cerevisiae. Mendenhall, M.D., Leeds, P., Fen, H., Mathison, L., Zwick, M., Sleiziz, C., Culbertson, M.R. J. Mol. Biol. (1987) [Pubmed]
Rearrangement of the genetic map of chromosome VII of Saccharomyces cerevisiae. Celenza, J.L., Carlson, M. Genetics (1985) [Pubmed]
MOL1, a Saccharomyces cerevisiae gene that is highly expressed in early stationary phase during growth on molasses. Praekelt, U.M., Meacock, P.A. Yeast (1992) [Pubmed]
Frameshift suppression Saccharomyces cerevisiae. II. Genetic properties of group II suppressors. Culbertson, M.R., Underbrink, K.M., Fink, G.R. Genetics (1980) [Pubmed]

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