The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SNG1  -  Sng1p

Saccharomyces cerevisiae S288c

Synonyms: G7591, Nitrosoguanidine resistance protein SNG1, YGR197C
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SNG1

  • Chromatin analysis revealed a switching-dependent unfolding of the donor loci mat2P and mat3M in the sng1(-) mutant, as indicated by increased accessibility to the in vivo-expressed Escherichia coli dam methylase [1].

High impact information on SNG1

  • This unique mutant phenotype defined a locus which we named sng1 (for silencing not governed) [1].
  • Sequencing of the HYR-mediating passenger DNA revealed that SNG1 encodes a 547 a polypeptide containing seven transmembrane-spanning regions that may be membrane-bound [2].
  • Outstanding features of some of these proteins were the homology of the putative protein coded by G7589 with proteins involved in transcription regulation and the transmembrane domains predicted in the putative protein coded by G7591 [3].
  • Comparison of the DNA sequence with established gene databanks revealed that SNG1 is a novel yeast gene [2].
  • We have molecularly characterized the SNG1 gene that confers hyper-resistance to the mutagen N-methyl-N'nitro-N-nitrosoguanidine (MNNG) in Saccharomyces cerevisiae when overexpressed on a multi-copy plasmid [2].

Biological context of SNG1


  1. A novel function of the DNA repair gene rhp6 in mating-type silencing by chromatin remodeling in fission yeast. Singh, J., Goel, V., Klar, A.J. Mol. Cell. Biol. (1998) [Pubmed]
  2. SNG1--a new gene involved in nitrosoguanidine resistance in Saccharomyces cerevisiae. Grey, M., Pich, C.T., Haase, E., Brendel, M. Mutat. Res. (1995) [Pubmed]
  3. The complete sequence of a 9000 bp fragment of the right arm of Saccharomyces cerevisiae chromosome VII contains four previously unknown open reading frames. Guerreiro, P., Silva, A.M., Barreiros, T., Arroyo, J., García-Gonzalez, M., García-Saez, M.I., Rodrigues-Pousada, C., Nombela, C. Yeast (1995) [Pubmed]
  4. Isolation and characterization of additional genes influencing resistance to various mutagens in the yeast Saccharomyces cerevisiae. Haase, E., Servos, J., Brendel, M. Curr. Genet. (1992) [Pubmed]
WikiGenes - Universities