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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PUP2  -  proteasome core particle subunit alpha 5

Saccharomyces cerevisiae S288c

Synonyms: DOA5, G9155, Macropain subunit PUP2, Multicatalytic endopeptidase complex subunit PUP2, Proteasome component PUP2, ...
 
 
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High impact information on PUP2

  • We demonstrate here that Doa3 and Doa5, two essential components of the DOA pathway, are subunits of the proteasome [1].
  • Finally, gene disruption experiments demonstrate that PUP2 belongs to the class of yeast proteasomal subunits that are essential for cell viability [2].
  • We identify alpha6/C2, alpha3/C9, and alpha5/Pup2 proteasome subunits as the main in vivo phosphorylated and in vitro CK2-phosphorylatable proteasome components [3].

References

  1. Biogenesis, structure and function of the yeast 20S proteasome. Chen, P., Hochstrasser, M. EMBO J. (1995) [Pubmed]
  2. Molecular cloning of an essential yeast gene encoding a proteasomal subunit. Georgatsou, E., Georgakopoulos, T., Thireos, G. FEBS Lett. (1992) [Pubmed]
  3. In vivo and in vitro phosphorylation of Candida albicans 20S proteasome. Fernández Murray, P., Pardo, P.S., Zelada, A.M., Passeron, S. Arch. Biochem. Biophys. (2002) [Pubmed]
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