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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SCW4  -  Scw4p

Saccharomyces cerevisiae S288c

Synonyms: Soluble cell wall protein 4, YGR279C
 
 
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High impact information on SCW4

  • However, Scw4p, Scw10p, and Tos1p do not contain internal repeat sequences shown to be essential for Pir protein incorporation and may represent a separate class of CWPs [1].
  • The amino acid sequence analysis of tryptic and chymotryptic peptides of MP65 demonstrated a substantial homology with the deduced sequences of two cell wall proteins of Saccharomyces cerevisiae, encoded by the genes YRM305C and YGR279C [2].
  • The double knockout of SCW4 and the homologous gene SCW10 resulted in slower growth, significantly increased release of proteins from intact cells by DTT, and highly decreased mating efficiency when these two genes were disrupted in both mating types [3].
  • One protein was related to the PIR protein family, whereas the remaining three (Scw3p, Scw4p, and Scw10p [for soluble cell wall proteins]) were found to be related to glucanases [3].
 

Anatomical context of SCW4

  • The data suggest that Scw4p and Scw10p act as glucanases or transglucosidases in concert with other cell-wall proteins to assure cell-wall integrity [4].

References

  1. Comprehensive proteomic analysis of Saccharomyces cerevisiae cell walls: identification of proteins covalently attached via glycosylphosphatidylinositol remnants or mild alkali-sensitive linkages. Yin, Q.Y., de Groot, P.W., Dekker, H.L., de Jong, L., Klis, F.M., de Koster, C.G. J. Biol. Chem. (2005) [Pubmed]
  2. Biochemical and immunological characterization of MP65, a major mannoprotein antigen of the opportunistic human pathogen Candida albicans. Gomez, M.J., Maras, B., Barca, A., La Valle, R., Barra, D., Cassone, A. Infect. Immun. (2000) [Pubmed]
  3. New potential cell wall glucanases of Saccharomyces cerevisiae and their involvement in mating. Cappellaro, C., Mrsa, V., Tanner, W. J. Bacteriol. (1998) [Pubmed]
  4. Scw10p, a cell-wall glucanase/transglucosidase important for cell-wall stability in Saccharomyces cerevisiae. Sestak, S., Hagen, I., Tanner, W., Strahl, S. Microbiology (Reading, Engl.) (2004) [Pubmed]
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