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Gene Review

RPL39  -  ribosomal 60S subunit protein L39

Saccharomyces cerevisiae S288c

Synonyms: 60S ribosomal protein L39, J0360, L46, RPL46, SPB2, ...
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High impact information on RPL39

  • The aberrant production of 25S ribosomal RNA (rRNA) occurring in spb4-1 mutants or the deletion of SPB2 (RPL46) permits the deletion of PAB1 [1].
  • Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46 [1].
  • Cloning of the L46 + S24 gene including the intergenic region in a multicopy yeast vector indicated that both genes are transcriptionally active [2].
  • Analysis of a construct in which the RPG-boxes were selectively deleted from the promoter region of the L46 gene indicated that the RPG-boxes are needed for efficient transcriptional activation of the L46 gene [2].
  • The protein shows substantial sequence homology to the eukaryotic ribosomal proteins L39 in rat and L46 in yeast [3].

Biological context of RPL39

  • To investigate whether the two RPG-boxes mediate transcription activation of both the L46 and S24 gene, two experimental strategies were followed: cloning of the respective genes on multicopy vectors and construction of fusion genes [2].
  • Unlike most yeast ribosomal protein genes studied so far the genes coding for S24 and L46 are adjacent on the genome [4].


  1. Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46. Sachs, A.B., Davis, R.W. Science (1990) [Pubmed]
  2. The divergently transcribed genes encoding yeast ribosomal proteins L46 and S24 are activated by shared RPG-boxes. Kraakman, L.S., Mager, W.H., Maurer, K.T., Nieuwint, R.T., Planta, R.J. Nucleic Acids Res. (1989) [Pubmed]
  3. A small basic ribosomal protein in Sulfolobus solfataricus equivalent to L46 in yeast: structure of the protein and its gene. Ramirez, C., Louie, K.A., Matheson, A.T. FEBS Lett. (1989) [Pubmed]
  4. The genes for yeast ribosomal proteins S24 and L46 are adjacent and divergently transcribed. Leer, R.J., van Raamsdonk-Duin, M.M., Kraakman, P., Mager, W.H., Planta, R.J. Nucleic Acids Res. (1985) [Pubmed]
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