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Gene Review:

SAP185 - Sap185p

Saccharomyces cerevisiae S288c

Synonyms: J0840, SIT4-associating protein SAP185, YJL098W

Jablonowski, D. et al., Manlandro, C.M. et al., Mallet, L. et al., Luke, M.M. et al., Rohde, J.R. et al.

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High impact information on SAP185

Sap155, Sap185, or Sap190 can restore these responses [1].
By sequence homology, we isolated two additional SAP genes, SAP185 and SAP4 [2].
Zymocin sensitivity therefore requires a Sap185p/Sap190p-dependent function of Sit4p protein phosphatase [3].
Functional cloning of the adenylate cyclase gene of Candida albicans in Saccharomyces cerevisiae within a genomic fragment containing five other genes, including homologues of CHS6 and SAP185 [4].
In contrast, a homolog of SAP155, called SAP185, encodes a positive modulator of K+ efflux: overexpression of SAP185 increases efflux, whereas deletion decreases efflux [5].

Biological context of SAP185

Both SAP155 and SAP185 require the presence of SIT4 for function, which encodes a PP2A-like phosphatase important for the G1-S transition through the cell cycle [5].

Other interactions of SAP185

Increased SAP155 dosage protects cells by influencing the sensitivity of the intracellular target and is unique among the four SAP genes in conferring zymocin resistance in high copy, but is antagonized by high-copy SAP185 or SAP190 [3].

References

TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors. Rohde, J.R., Campbell, S., Zurita-Martinez, S.A., Cutler, N.S., Ashe, M., Cardenas, M.E. Mol. Cell. Biol. (2004) [Pubmed]
The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase. Luke, M.M., Della Seta, F., Di Como, C.J., Sugimoto, H., Kobayashi, R., Arndt, K.T. Mol. Cell. Biol. (1996) [Pubmed]
Sit4p protein phosphatase is required for sensitivity of Saccharomyces cerevisiae to Kluyveromyces lactis zymocin. Jablonowski, D., Butler, A.R., Fichtner, L., Gardiner, D., Schaffrath, R., Stark, M.J. Genetics (2001) [Pubmed]
Functional cloning of the adenylate cyclase gene of Candida albicans in Saccharomyces cerevisiae within a genomic fragment containing five other genes, including homologues of CHS6 and SAP185. Mallet, L., Renault, G., Jacquet, M. Yeast (2000) [Pubmed]
Ability of Sit4p to promote K+ efflux via Nha1p is modulated by Sap155p and Sap185p. Manlandro, C.M., Haydon, D.H., Rosenwald, A.G. Eukaryotic Cell (2005) [Pubmed]

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