The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

TIM54  -  Tim54p

Saccharomyces cerevisiae S288c

Synonyms: J1150, Mitochondrial import inner membrane translocase subunit TIM54, YJL054W
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on TIM54

  • Proteins destined for internal mitochondrial compartments interact subsequently with one of the two distinct protein Translocases of the Inner Mitochondrial membrane (TIM23 and TIM54 complexes) or follow specialized paths into the intermembrane space [1].
  • The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane [2].
  • Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane [3].
  • The positively charged amino-terminal region of Tim54 is required for membrane translocation but not for targeting to Tom70 [4].
 

Other interactions of TIM54

References

  1. Tom40, the import channel of the mitochondrial outer membrane, plays an active role in sorting imported proteins. Gabriel, K., Egan, B., Lithgow, T. EMBO J. (2003) [Pubmed]
  2. The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane. Kerscher, O., Holder, J., Srinivasan, M., Leung, R.S., Jensen, R.E. J. Cell Biol. (1997) [Pubmed]
  3. Tim18p is a new component of the Tim54p-Tim22p translocon in the mitochondrial inner membrane. Kerscher, O., Sepuri, N.B., Jensen, R.E. Mol. Biol. Cell (2000) [Pubmed]
  4. Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway. Kurz, M., Martin, H., Rassow, J., Pfanner, N., Ryan, M.T. Mol. Biol. Cell (1999) [Pubmed]
  5. Tim54p connects inner membrane assembly and proteolytic pathways in the mitochondrion. Hwang, D.K., Claypool, S.M., Leuenberger, D., Tienson, H.L., Koehler, C.M. J. Cell Biol. (2007) [Pubmed]
 
WikiGenes - Universities