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Gene Review:

APL1 - Apl1p

Saccharomyces cerevisiae S288c

Synonyms: AP-2 complex subunit beta, Beta-2-adaptin, Beta-adaptin, Clathrin assembly protein complex 2 beta large chain, Clathrin assembly protein large beta chain, ...

Rad, M.R. et al., Sychrova, H. et al.

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High impact information on APL1

APl1 or APl2 disruptions (apl1 delta or apl2 delta) yield no discernable phenotypes in CHC1 strains, indicating that the Apl proteins are not essential for clathrin function [1].
The gene, which was named APL1 (Amino-acid Permase Like), is located 881 bp upstream from LYP1 (lysine-specific permease), and in head-to-head orientation to it [2].

Other interactions of APL1

However, the apl2 delta, but not the apl1 delta, allele enhances the growth and alpha-factor pheromone maturation defects of chc1-ts cells [1].

References

Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions. Rad, M.R., Phan, H.L., Kirchrath, L., Tan, P.K., Kirchhausen, T., Hollenberg, C.P., Payne, G.S. J. Cell. Sci. (1995) [Pubmed]
APL1, a yeast gene encoding a putative permease for basic amino acids. Sychrova, H., Chevallier, M.R. Yeast (1994) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AGOS_ADR342C	Ashbya gossypii ATCC 10895
KLLA0E09527g	Kluyveromyces lactis NRRL Y-1140
MGG_04150	Magnaporthe oryzae 70-15
NCU05232	Neurospora crassa OR74A
apl1	Schizosaccharomyces pombe 972h-

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