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Gene Review:

APL2 - Apl2p

Saccharomyces cerevisiae S288c

Synonyms: AP-1 complex subunit beta-1, Beta-1-adaptin, Clathrin assembly protein complex 1 beta-1 large chain, Clathrin assembly protein large beta-1 chain, YKL135C

Rad, M.R. et al., Nikawa, J. et al., Deloche, O. et al.

Nikawa, Yata, Motomura, Miyoshi, Ueda, Hisada,

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High impact information on APL2

However, Vps10p sorting is independent of Apl2p [1].
APl1 or APl2 disruptions (apl1 delta or apl2 delta) yield no discernable phenotypes in CHC1 strains, indicating that the Apl proteins are not essential for clathrin function [2].
These Golgi-specific effects of apl2 delta in chc1-ts cells provide evidence that Apl2p is a component of an AP complex that interacts with clathrin at the Golgi apparatus [2].
INO2-APL2 double disruptants also showed growth inability in non-fermentable carbon sources, such as glycerol [3].
Ino2p and Ino4p bind to Apl2p independently, but more strongly when both are present [3].

Biological context of APL2

Furthermore, a disruption of APL2 together with INO2 or INO4 rendered yeast cells sensitive to oxidative stress [3].

Other interactions of APL2

However, the apl2 delta, but not the apl1 delta, allele enhances the growth and alpha-factor pheromone maturation defects of chc1-ts cells [2].
We found that Ino2p, Ino4p, and Apl2p form a ternary complex [3].

References

Vps10p transport from the trans-Golgi network to the endosome is mediated by clathrin-coated vesicles. Deloche, O., Yeung, B.G., Payne, G.S., Schekman, R. Mol. Biol. Cell (2001) [Pubmed]
Saccharomyces cerevisiae Apl2p, a homologue of the mammalian clathrin AP beta subunit, plays a role in clathrin-dependent Golgi functions. Rad, M.R., Phan, H.L., Kirchrath, L., Tan, P.K., Kirchhausen, T., Hollenberg, C.P., Payne, G.S. J. Cell. Sci. (1995) [Pubmed]
Ternary complex formation of ino2p-ino4p transcription factors and apl2p adaptin Beta subunit in yeast. Nikawa, J., Yata, M., Motomura, M., Miyoshi, N., Ueda, T., Hisada, D. Biosci. Biotechnol. Biochem. (2006) [Pubmed]

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AGOS_AFR200W	Ashbya gossypii ATCC 10895
KLLA0E12255g	Kluyveromyces lactis NRRL Y-1140

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