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Gene Review

MAK11  -  Mak11p

Saccharomyces cerevisiae S288c

Synonyms: Maintenance of killer protein 11, Protein MAK11, YKL021C
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High impact information on MAK11

  • It is thus likely that the previously observed phenotypes for MAK11 homologues in other eukaryotes are secondary to the main function of these proteins in ribosome formation [1].
  • We have previously shown that budding yeast Mak11, whose homologues in other eukaryotes were described as modulating a p21-activated protein kinase function, accumulates in Rlp24-associated pre-60S complexes when their maturation is impeded in Saccharomyces cerevisiae [1].
  • Moreover, we found that Skb15, the Mak11 homologue in Schizosaccharomyces pombe, also associated with preribosomes and affected 60S biogenesis in fission yeast [1].
  • While the mak11-1 mutation results in specific loss of M1 double-stranded RNA without any apparent growth defect, replacing a 792-base pair internal EcoRV fragment of MAK11 with the URA3 gene (gene disruption) resulted in a lethal mutation [2].
  • The MAK11 protein is essential for cell growth and replication of M double-stranded RNA and is apparently a membrane-associated protein [2].

Biological context of MAK11


Associations of MAK11 with chemical compounds

  • The C-terminal region is lysine-rich and is necessary for mak11-complementing activity [2].

Other interactions of MAK11

  • We cloned MAK11, MAK18, and MKT1 utilizing their genetic map positions [4].
  • A 17.5 kb DNA fragment of chromosome XI, located between the genetic loci mif2 and mak11 was sequenced and analysed [5].


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