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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NTR2  -  Ntr2p

Saccharomyces cerevisiae S288c

Synonyms: NTC-related protein 2, Nineteen complex-related protein 2, Pre-mRNA-splicing factor NTR2, YKR022C
 
 
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High impact information on NTR2

  • The affinity-purified Ntr1-Ntr2-Prp43 complex could catalyze disassembly of the spliceosome in an ATP-dependent manner, separating U2, U5, U6, NTC (NineTeen Complex), and lariat-intron [1].
  • Ntr1 and Ntr2 (NineTeen complex-Related proteins) were identified for their weak association with components of the Prp19-associated complex [1].
  • Immunoprecipitation analysis revealed that Ntr1 and Ntr2 formed a stable complex with DExD/H-box RNA helicase Prp43 in the splicing extract [1].
 

Biological context of NTR2

  • We propose that Ntr1 promotes release of excised introns from splicing complexes by acting as a spliceosome receptor or RNA-targeting factor for Prp43, possibly assisted by the Ntr2 protein [2].

References

  1. Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2. Tsai, R.T., Fu, R.H., Yeh, F.L., Tseng, C.K., Lin, Y.C., Huang, Y.H., Cheng, S.C. Genes Dev. (2005) [Pubmed]
  2. Yeast ntr1/spp382 mediates prp43 function in postspliceosomes. Boon, K.L., Auchynnikava, T., Edwalds-Gilbert, G., Barrass, J.D., Droop, A.P., Dez, C., Beggs, J.D. Mol. Cell. Biol. (2006) [Pubmed]
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