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Gene Review: 

RPS21A  -  ribosomal 40S subunit protein S21A

Saccharomyces cerevisiae S288c

Synonyms: 40S ribosomal protein S21-A, RPS25, RPS25A, RPS26A, S26, ...
 
 
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Disease relevance of RPS21A

 

High impact information on RPS21A

  • Cloning and nucleotide sequence of the gene encoding yeast ribosomal protein YS25 [2].
  • Protein YS25 and its counterparts, SP-S28 and rat S21 [nomenclature according to Sherton, C. C., & Wool, I. G. (1972) J. Biol. Chem. 247, 4460-4467], from Saccharomyces cerevisiae, Schizosaccharomyces pombe, and rat liver cytoplasmic ribosomes, respectively, were sequenced by a combination of various enzymatic digestions and/or chemical cleavage [3].
  • The deduced amino-acid sequence of this gene is highly homologous to the YS25 ribosomal protein of Saccharomyces cerevisiae [4].
  • Relative to the wild type, cells with disrupted RPS21A or RPS21B genes exhibit a reduction in growth rate, a decrease in free 40S subunits, an increase in the amount of free 60S subunits, and a decrease in polysome size [5].

References

  1. Examination of protein sequence homologies: III. Ribosomal protein YS25 from Saccharomyces cerevisiae and its counterparts from Schizosaccharomyces pombe, rat liver, and Escherichia coli. Otaka, E., Ooi, T., Itoh, T., Kumazaki, T. J. Mol. Evol. (1986) [Pubmed]
  2. Cloning and nucleotide sequence of the gene encoding yeast ribosomal protein YS25. Suzuki, K., Otaka, E. Nucleic Acids Res. (1988) [Pubmed]
  3. Primary structures of ribosomal protein YS25 from Saccharomyces cerevisiae and its counterparts from Schizosaccharomyces pombe and rat liver. Itoh, T., Otaka, E., Matsui, K.A. Biochemistry (1985) [Pubmed]
  4. Characterization and expression of a Neurospora crassa ribosomal protein gene, crp-7. Kusuda, M., Yajima, H., Inoue, H. Curr. Genet. (2000) [Pubmed]
  5. Ribosomal proteins Rps0 and Rps21 of Saccharomyces cerevisiae have overlapping functions in the maturation of the 3' end of 18S rRNA. Tabb-Massey, A., Caffrey, J.M., Logsden, P., Taylor, S., Trent, J.O., Ellis, S.R. Nucleic Acids Res. (2003) [Pubmed]
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