Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

LAS1 - Las1p

Saccharomyces cerevisiae S288c

Synonyms: Protein LAS1, YKR063C

Doseff, A.I. et al., Rachlin, A.S. et al., Suzuki, M. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on LAS1

Sequence analysis of 140 kDa palladin revealed a conserved binding site for SH3 domains, suggesting that it binds directly to the SH3-domain protein Lasp-1 [1].
Overexpression of LAS1 results in extra cell surface projections in the mother cell, alterations in actin and SPA2 localization, and the accumulation of electron-dense structures along the periphery of both the mother cell and the bud [2].
LAS1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth [2].
The Arabidopsis gene At3g45130, designated LAS1, encodes a functional lanosterol synthase in plants [3].

References

Identification of palladin isoforms and characterization of an isoform-specific interaction between Lasp-1 and palladin. Rachlin, A.S., Otey, C.A. J. Cell. Sci. (2006) [Pubmed]
LAS1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth. Doseff, A.I., Arndt, K.T. Genetics (1995) [Pubmed]
Lanosterol synthase in dicotyledonous plants. Suzuki, M., Xiang, T., Ohyama, K., Seki, H., Saito, K., Muranaka, T., Hayashi, H., Katsube, Y., Kushiro, T., Shibuya, M., Ebizuka, Y. Plant Cell Physiol. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AGOS_ACR242W	Ashbya gossypii ATCC 10895
KLLA0A06017g	Kluyveromyces lactis NRRL Y-1140

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share