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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GRE2  -  methylglyoxal reductase (NADPH-dependent)...

Saccharomyces cerevisiae S288c

Synonyms: 3-methylbutanal reductase, Genes de respuesta a estres protein 2, Isovaleraldehyde reductase, NADPH-dependent methylglyoxal reductase GRE2, YOL151W
 
 
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High impact information on GRE2

  • However, the two other yeast CRE-binding proteins, Aca1p and Aca2p, are not involved in regulation of the GRE2 promoter under osmotic stress [1].
  • We sought to improve the performance of baker's yeast for beta-keto ester reductions by using recombinant DNA techniques to alter the levels of three enzymes known to play important roles in these reactions (fatty acid synthase, Fasp; aldo-keto reductase, Ypr1p; alpha-acetoxy ketone reductase, Gre2p) [2].
  • We show that methylglyoxal reductase (NADPH-dependent) is encoded by GRE2 (YOL151w) [3].
  • The three of them are under the control of the HOG pathway, even though GRE1 and GRE2 promoter regions do not present the consensus core STRE sequence [4].

References

  1. The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage. Rep, M., Proft, M., Remize, F., Tamás, M., Serrano, R., Thevelein, J.M., Hohmann, S. Mol. Microbiol. (2001) [Pubmed]
  2. Highly stereoselective reagents for beta-keto ester reductions by genetic engineering of baker's yeast. Rodríguez, S., Kayser, M.M., Stewart, J.D. J. Am. Chem. Soc. (2001) [Pubmed]
  3. Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae. Chen, C.N., Porubleva, L., Shearer, G., Svrakic, M., Holden, L.G., Dover, J.L., Johnston, M., Chitnis, P.R., Kohl, D.H. Yeast (2003) [Pubmed]
  4. Three genes whose expression is induced by stress in Saccharomyces cerevisiae. Garay-Arroyo, A., Covarrubias, A.A. Yeast (1999) [Pubmed]
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