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Gene Review

HST1  -  Hst1p

Saccharomyces cerevisiae S288c

Synonyms: Homologous to SIR2 protein 1, NAD-dependent protein deacetylase HST1, Regulatory protein SIR2 homolog 1, YOL068C
 
 
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High impact information on HST1

  • The DAL cluster is located in a domain of modified chromatin involving both H2A.Z histone exchange and Hst1-Sum1-mediated histone deacetylation, and it may be a coadapted gene complex formed by epistatic selection [1].
  • The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program [2].
  • Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae [3].
  • Furthermore, PNC1 overexpression suppresses the inhibitory effect of exogenously added NAM on silencing, life span, and Hst1-mediated transcriptional repression [4].
  • A series of compounds based on a splitomicin derivative, dehydrosplitomicin (compound 2), effectively phenocopied a yeast strain that lacked Hst1 deacetylase while having no effect on the silencing activities of Sir2 [5].
 

Biological context of HST1

  • A high-copy suppressor gene, HST1, for the TFP and Ca2+ sensitivities of ssd1 null mutant was cloned and sequenced [6].
 

Other interactions of HST1

  • SUM1 and HST1, genes previously associated with transcriptional silencing, are required for MSE-mediated repression [3].
  • Recently, it has been shown that Sum1-1p is directed to the silencers and internal regions of the HM loci, and interacts with the Hst1p histone deacetylase that is a paralog of the Sir2p histone deacetylase [7].

References

  1. Birth of a metabolic gene cluster in yeast by adaptive gene relocation. Wong, S., Wolfe, K.H. Nat. Genet. (2005) [Pubmed]
  2. The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Pijnappel, W.W., Schaft, D., Roguev, A., Shevchenko, A., Tekotte, H., Wilm, M., Rigaut, G., Séraphin, B., Aasland, R., Stewart, A.F. Genes Dev. (2001) [Pubmed]
  3. Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. Xie, J., Pierce, M., Gailus-Durner, V., Wagner, M., Winter, E., Vershon, A.K. EMBO J. (1999) [Pubmed]
  4. Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. Gallo, C.M., Smith, D.L., Smith, J.S. Mol. Cell. Biol. (2004) [Pubmed]
  5. Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast. Hirao, M., Posakony, J., Nelson, M., Hruby, H., Jung, M., Simon, J.A., Bedalov, A. J. Biol. Chem. (2003) [Pubmed]
  6. The Saccharomyces cerevisiae SSD1 gene is involved in the tolerance to high concentration of Ca2+ with the participation of HST1/NRC1/BFR1. Tsuchiya, E., Matsuzaki, G., Kurano, K., Fukuchi, T., Tsukao, A., Miyakawa, T. Gene (1996) [Pubmed]
  7. Structural analyses of Sum1-1p-dependent transcriptionally silent chromatin in Saccharomyces cerevisiae. Yu, Q., Elizondo, S., Bi, X. J. Mol. Biol. (2006) [Pubmed]
 
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