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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PRE6  -  proteasome core particle subunit alpha 4

Saccharomyces cerevisiae S288c

Synonyms: Macropain subunit PRE6, Multicatalytic endopeptidase complex subunit PRE6, Proteasome component PRE6, Proteasome subunit alpha type-4, Proteinase YSCE subunit PRE6, ...
 
 
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High impact information on PRE6

  • Importantly, biogenesis of proteasomes is delayed at an early stage in pre9Delta cells, suggesting an advantage for Pre9 over Pre6 incorporation at the alpha3 position that facilitates correct assembly [1].
  • An alpha subunit of the proteolytically active 20S core complex of the 26S proteasome, Pre6/YOL038w, as well as an ATPase-type subunit of the regulatory 19S cap complex, Cim5/YOL145w, were tagged with GFP [2].
  • Including the Pre5 and Pre6 proteins, every subgroup contains a single yeast member [3].

References

  1. Plasticity in eucaryotic 20S proteasome ring assembly revealed by a subunit deletion in yeast. Velichutina, I., Connerly, P.L., Arendt, C.S., Li, X., Hochstrasser, M. EMBO J. (2004) [Pubmed]
  2. Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast. Enenkel, C., Lehmann, A., Kloetzel, P.M. EMBO J. (1998) [Pubmed]
  3. PRE5 and PRE6, the last missing genes encoding 20S proteasome subunits from yeast? Indication for a set of 14 different subunits in the eukaryotic proteasome core. Heinemeyer, W., Tröndle, N., Albrecht, G., Wolf, D.H. Biochemistry (1994) [Pubmed]
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