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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CMK2  -  Cmk2p

Saccharomyces cerevisiae S288c

Synonyms: Calcium/calmodulin-dependent protein kinase II, YOL016C
 
 
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High impact information on CMK2

  • Calmodulin is also required for endocytosis in yeast and participates in Ca2+-dependent, stress-activated signaling pathways through its regulation of a protein phosphatase, calcineurin, and the protein kinases, Cmk1p and Cmk2p [1].
  • The CMK1 and CMK2 products expressed in bacteria were found to have different biochemical properties in terms of autoregulatory activity and preference for yeast CaM or bovine CaM for maximal activity [2].
 

Biological context of CMK2

  • Deletion of the CMK1 and CMK2 genes, which encode CaMK, decreases the LD50 of pheromone compared with that for a wild-type strain but again has no effect in a cmd1-6 strain [3].
 

Regulatory relationships of CMK2

  • Antibody raised against a peptide fragment of the CMK1 protein cross-reacts with the CMK2 product [2].
 

Other interactions of CMK2

  • Another gene may be substituted for function of the CMK1 and CMK2 kinase in vivo, since elimination of both kinase genes is not lethal [2].
 

Analytical, diagnostic and therapeutic context of CMK2

  • Immunoblotting with this antibody indicated that the CMK1 and CMK2 products have apparent molecular masses of 56 and 50 kDa, respectively, in yeast cells [2].

References

  1. Genetic analysis of calmodulin and its targets in Saccharomyces cerevisiae. Cyert, M.S. Annu. Rev. Genet. (2001) [Pubmed]
  2. Two yeast genes encoding calmodulin-dependent protein kinases. Isolation, sequencing and bacterial expressions of CMK1 and CMK2. Ohya, Y., Kawasaki, H., Suzuki, K., Londesborough, J., Anraku, Y. J. Biol. Chem. (1991) [Pubmed]
  3. Ca2+-calmodulin promotes survival of pheromone-induced growth arrest by activation of calcineurin and Ca2+-calmodulin-dependent protein kinase. Moser, M.J., Geiser, J.R., Davis, T.N. Mol. Cell. Biol. (1996) [Pubmed]
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